Prion protein and its interactions with metal ions (Cu2+, Zn2+, and Cd2+) and metallothionein 3

Prion protein and its interactions with metal ions (Cu2+, Zn2+, and Cd2+) and metallothionein 3

The effects of heavy metals (Zn2+, Cu2+, and/or Cd2+) on Escherichia coli expressing either prion (hPrPC ) or metallothionein 3 (MT-3) brain proteins capable of binding these metals were investigated. The expression of hPrPC or MT-3 in E.coli was confirmed using western-blot and dot-blot methods. Af...

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Bibliographic Details
Main Authors: Branislav Ruttkay-Nedecky, Eliska Sedlackova, Dagmar Chudobova, Kristyna Cihalova, Ana Maria Jimenez Jimenez, Sona Krizkova, Lukas Richtera, Vojtech Adam, Rene Kizek
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2015-09-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/191

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http://pub.iapchem.org/ojs/index.php/admet/article/view/191

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