Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion

Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion

We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution. Wet-milled GF nanosuspensions containing a polymer (Sol: Soluplus<sup>...

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Bibliographic Details
Main Authors: Meng Li, Casey Furey, Jeffrey Skros, Olivia Xu, Mahbubur Rahman, Mohammad Azad, Rajesh Dave, Ecevit Bilgili
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
nanocomposites
amorphous solid dispersion
wet media milling
nanoextrusion
wettability
dissolution
Online Access:https://www.mdpi.com/1999-4923/13/7/1036

Internet

https://www.mdpi.com/1999-4923/13/7/1036

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