Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting Mpc1, an o...

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Bibliographic Details
Main Authors: Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720302035

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http://www.sciencedirect.com/science/article/pii/S2211124720302035

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