Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivity

Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivity

Using a murine model, topical application of glucocorticoid ([GC], 50 μg diflucortolone valerate in ethanol) on a sensitized site (flank skin) for 7 times before and 2 times after sensitization on alternate days, augmented expression of contact sensitivity reactions on the challenged site (ear skin)...

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Bibliographic Details
Main Authors: Ken Igawa, Ichiro Katayama, Kazuya Minatohara, Takahiro Satoh, Hiroo Yokozeki, Kiyoshi Nishioka
Format: Article
Language:English
Published: Elsevier 1997-01-01
Series:Allergology International
Subjects:
atopic dermatitis
contact sensitivity
Langerhans cell
steroid
Th 1and Th2 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015315781

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http://www.sciencedirect.com/science/article/pii/S1323893015315781

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