Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, and treatment of mice with a zonulin antagonist can...

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Bibliographic Details
Main Authors: Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Cañete, Francesco Ciccia, Georg Schett, Mario M. Zaiss
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15831-7

Internet

https://doi.org/10.1038/s41467-020-15831-7

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