tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

Abstract Background Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus erythematosus (SLE) and their potential function in the SLE pathogenes...

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Bibliographic Details
Main Authors: Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han, Shuang Ye
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Translational Medicine
Subjects:
tRNA derived fragments (tRFs)
Systemic lupus erythematosus (SLE)
CD4+ T cells
Oxidative phosphorylation (OXPHOS)
Type I interferon (IFN)
Online Access:https://doi.org/10.1186/s12967-021-02967-3

Internet

https://doi.org/10.1186/s12967-021-02967-3

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