TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations

TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations

Abstract TERT promoter (TERTp) mutations are found in the majority of World Health Organization (WHO) grade IV adult IDH wild-type glioblastoma (IDH-wt GBM). Here, we characterized the subset of IDH-wt GBMs that do not have TERTp mutations. In a cohort of 121 adult grade IV gliomas, we identified 10...

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Bibliographic Details
Main Authors: Erik A. Williams, Julie J. Miller, Shilpa S. Tummala, Tristan Penson, A. John Iafrate, Tareq A. Juratli, Daniel P. Cahill
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Acta Neuropathologica Communications
Subjects:
Glioma
PI3K pathway
TERT promoter
IDH1
H3F3A
BAF complex
Online Access:http://link.springer.com/article/10.1186/s40478-018-0613-2

Internet

http://link.springer.com/article/10.1186/s40478-018-0613-2

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