A Turn-on Fluorescence Sensor for Heparin Detection Based on a Release of Taiwan Cobra Cardiotoxin from a DNA Aptamer or Adenosine-Based Molecular Beacon

A Turn-on Fluorescence Sensor for Heparin Detection Based on a Release of Taiwan Cobra Cardiotoxin from a DNA Aptamer or Adenosine-Based Molecular Beacon

This study presents two sensitive fluorescent assays for sensing heparin on the basis of the electrostatic interaction between heparin and Naja naja atra cardiotoxin 3 (CTX3). Owing to CTX3-induced folded structure of an adenosine-based molecular beacon (MB) or a DNA aptamer against CTX3, a reductio...

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Bibliographic Details
Main Authors: Yi-Jun Shi, Liang-Jun Wang, Yuan-Chin Lee, Chia-Hui Huang, Wan-Ping Hu, Long-Sen Chang
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
aptamer
molecular beacon
cardiotoxin
heparin
turn-on fluorescence sensor
Online Access:http://www.mdpi.com/1420-3049/23/2/460

Internet

http://www.mdpi.com/1420-3049/23/2/460

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