SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress.

The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause replication interference. Using genetic and biochemical approaches, we have tested if derepression o...

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Bibliographic Details
Main Authors: Laura V Minard, Ling-ju Lin, Michael C Schultz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3124541?pdf=render