Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9

Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9

S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment and are considered as alarmins able to amplif...

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Bibliographic Details
Main Authors: Véronique Schenten, Sébastien Plançon, Nicolas Jung, Justine Hann, Jean-Luc Bueb, Sabrina Bréchard, Eric J. Tschirhart, Fabrice Tolle
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
neutrophils
S100A8/PhosphoA9
inflammation
cytokines
Toll-like receptor 4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00447/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00447/full

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