HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies.

HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies.

Use of Env in HIV vaccine development has been disappointing. Here we show that, in the presence of a biologically active Tat subunit vaccine, a trimeric Env protein prevents in monkeys virus spread from the portal of entry to regional lymph nodes. This appears to be due to specific interactions bet...

Full description

Bibliographic Details
Main Authors: Paolo Monini, Aurelio Cafaro, Indresh K Srivastava, Sonia Moretti, Victoria A Sharma, Claudia Andreini, Chiara Chiozzini, Flavia Ferrantelli, Maria R Pavone Cossut, Antonella Tripiciano, Filomena Nappi, Olimpia Longo, Stefania Bellino, Orietta Picconi, Emanuele Fanales-Belasio, Alessandra Borsetti, Elena Toschi, Ilaria Schiavoni, Ilaria Bacigalupo, Elaine Kan, Leonardo Sernicola, Maria T Maggiorella, Katy Montin, Marco Porcu, Patrizia Leone, Pasqualina Leone, Barbara Collacchi, Clelia Palladino, Barbara Ridolfi, Mario Falchi, Iole Macchia, Jeffrey B Ulmer, Stefano Buttò, Cecilia Sgadari, Mauro Magnani, Maurizio P M Federico, Fausto Titti, Lucia Banci, Franco Dallocchio, Rino Rappuoli, Fabrizio Ensoli, Susan W Barnett, Enrico Garaci, Barbara Ensoli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3496724?pdf=render

Internet

http://europepmc.org/articles/PMC3496724?pdf=render

Similar Items