A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease

Studies of Alzheimer’s disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-specific w...

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Bibliographic Details
Main Authors: Tenielle Porter, Samantha C. Burnham, Greg Savage, Yen Ying Lim, Paul Maruff, Lidija Milicic, Madeline Peretti, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, Kevin Taddei, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
polygenic risk score
Alzheimer’s disease
Aβ-amyloid
cognitive decline
episodic memory
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00423/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00423/full

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