High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population

High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population

Abstract Background Pathogenic BRCA1 founder mutations (c.4035delA, c.5266dupC) contribute to 3.77% of all consecutive primary breast cancers and 9.9% of all consecutive primary ovarian cancers. Identifying germline pathogenic gene variants in patients with primary breast and ovarian cancer could si...

Full description

Bibliographic Details
Main Authors: J. Maksimenko, A. Irmejs, G. Trofimovičs, D. Bērziņa, E. Skuja, G. Purkalne, E. Miklaševičs, J. Gardovskis
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
Pathogenic non-founder BRCA1/2 mutations
Triple-negative breast cancer
Familial breast cancer
Online Access:http://link.springer.com/article/10.1186/s13053-018-0094-0

Internet

http://link.springer.com/article/10.1186/s13053-018-0094-0

Similar Items