Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef

<p>Abstract</p> <p>Background</p> <p>Dendritic cells (DCs) are among the first cells to encounter HIV-1 and play important roles in viral transmission and pathogenesis. Immature DCs allow productive HIV-1 replication and long-term viral dissemination. The pro-inflammato...

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Bibliographic Details
Main Authors: Wu Li, Spearman Paul, Coleman Christopher M
Format: Article
Language:English
Published: BMC 2011-04-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/8/1/26