Population Pharmacokinetic Method to Predict Within-Subject Variability Using Single-Period Clinical Data

Population Pharmacokinetic Method to Predict Within-Subject Variability Using Single-Period Clinical Data

Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV). However, it is difficult to determine WSV without replicate-designed clinical trial data, and statisticians typically estimate optimal sample sizes usi...

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Bibliographic Details
Main Authors: Won-ho Kang, Jae-yeon Lee, Jung-woo Chae, Kyeong-Ryoon Lee, In-hwan Baek, Min-Soo Kim, Hyun-moon Back, Sangkeun Jung, Craig Shaffer, Rada Savic, Hwi-yeol Yun
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
interindividual variability
residual variability
pharmacokinetics
statistical modeling
Online Access:https://www.mdpi.com/1424-8247/14/2/114

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https://www.mdpi.com/1424-8247/14/2/114

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