β-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure.

β-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure.

Long-term β-adrenergic receptor (β-AR) blockade reduces mortality in patients with heart failure. Chronic sympathetic hyperactivity in heart failure causes sustained β-AR activation, and this can deplete Ca(2+) in endoplasmic reticulum (ER) leading to ER stress and subsequent apoptosis. We tested th...

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Bibliographic Details
Main Authors: Li Ni, Changqing Zhou, Quanlu Duan, Jiagao Lv, Xiangning Fu, Yong Xia, Dao Wen Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3206949?pdf=render

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http://europepmc.org/articles/PMC3206949?pdf=render

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