Mitochondrial DNMT3A and DNA Methylation in Skeletal Muscle and CNS of Transgenic Mouse Models of ALS

Mitochondrial DNMT3A and DNA Methylation in Skeletal Muscle and CNS of Transgenic Mouse Models of ALS

Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have relative underrepresentation; however, possible tissue and cell differences in mtDNA methylation and relationships to neurodegenerative...

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Bibliographic Details
Main Authors: Margaret eWong, Barry eGertz, Barry A Chestnut, Lee J Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
5-Methylcytosine
motor neuron
ALS
mitochondrial DNA
DNA pyrosequencing
Dnmt1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00279/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00279/full

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