HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

Hepatitis C virus (HCV) infection is accompanied by the induction of oxidative stress, mediated by several virus proteins, the most prominent being the nucleocapsid protein (HCV core). Here, using the truncated forms of HCV core, we have delineated several mechanisms by which it induces the oxidativ...

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Bibliographic Details
Main Authors: Alexander V. Ivanov, Olga A. Smirnova, Irina Y. Petrushanko, Olga N. Ivanova, Inna L. Karpenko, Ekaterina Alekseeva, Irina Sominskaya, Alexander A. Makarov, Birke Bartosch, Sergey N. Kochetkov, Maria G. Isaguliants
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Viruses
Subjects:
hepatitis C virus
oxidative stress
reactive oxygen species
NADPH oxidase
transforming growth factor
cytochrome P450
ER oxidoreductin
Online Access:http://www.mdpi.com/1999-4915/7/6/2745

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http://www.mdpi.com/1999-4915/7/6/2745

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