Interruption of CD40 Pathway Improves Efficacy of Transplanted Endothelial Progenitor Cells in Monocrotaline Induced Pulmonary Arterial Hypertension

Interruption of CD40 Pathway Improves Efficacy of Transplanted Endothelial Progenitor Cells in Monocrotaline Induced Pulmonary Arterial Hypertension

Background/Aims: Transplantation of endothelial progenitor cells (EPCs) plays a therapeutic role in pulmonary arterial hypertension (PAH). Meanwhile, recruitment of progenitors has potential inflammatory effects and exaggerates vascular injury. CD40 pathway is identified as a major player in vascula...

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Bibliographic Details
Main Authors: YanYun Pan, Shuai Wang, JinXiu Yang, Bin Chen, ZeWei Sun, LiFang Ye, JianHua Zhu, XingXiang Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
CD40/CD40L
Pulmonary arterial hypertension
Endothelial progenitor cells
Online Access:http://www.karger.com/Article/FullText/430130

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http://www.karger.com/Article/FullText/430130

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