Replacing the 238th aspartic acid with an arginine impaired the oligomerization activity and inflammation-inducing property of pyolysin

Replacing the 238th aspartic acid with an arginine impaired the oligomerization activity and inflammation-inducing property of pyolysin

Trueperella pyogenes (T. pyogenes) is an important opportunistic pathogen. Pyolysin (PLO) importantly contributes to the pathogenicity of T. pyogenes. However, the relationship between the structure and function and the virulence of PLO is not well documented. In the current study, recombinant PLO (...

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Bibliographic Details
Main Authors: Wenlong Zhang, Haili Wang, Bing Wang, Yue Zhang, Yunhao Hu, Bo Ma, Junwei Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Trueperella pyogenes
pyolysin
oligomerization
pore-forming activity
inflammation response
Online Access:http://dx.doi.org/10.1080/21505594.2018.1491256

Internet

http://dx.doi.org/10.1080/21505594.2018.1491256

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