In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter.

In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter.

PURPOSE:To develop a superior VAChT imaging probe for SPECT, radiolabeled (-)-OIDV and (+)-OIDV were isolated and investigated for differences in their binding affinity and selectivity to VAChT, as well as their in vivo activities. PROCEDURES:Radioiodinated o-iodo-trans-decalinvesamicol ([125I]OIDV)...

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Bibliographic Details
Main Authors: Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Mohammad Anwar-Ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4713475?pdf=render

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http://europepmc.org/articles/PMC4713475?pdf=render

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