Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

Summary: The tyrosine kinase receptor ephrin receptor A2 (EPHA2) is overexpressed in lung (LSCC) and head and neck (HNSCC) squamous cell carcinomas. Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 and Y772, it can promote tumorigenesis in a ligand-i...

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Bibliographic Details
Main Authors: Saumya Srivastava, Ka Ming Pang, Mari Iida, Michael S. Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Raju Pillai, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler, Ravi Salgia
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biological Sciences
Cell Biology
Molecular Biology
Cancer Systems Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308841

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http://www.sciencedirect.com/science/article/pii/S2589004220308841

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