scDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured
Abstract A pressing challenge in single-cell transcriptomics is to benchmark experimental protocols and computational methods. A solution is to use computational simulators, but existing simulators cannot simultaneously achieve three goals: preserving genes, capturing gene correlations, and generati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-021-02367-2 |