Effect of methotrexate and doxorubicin cumulative doses on superoxide dismutase levels in childhood acute lymphoblastic leukemia

Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Chemotherapeutic drugs for ALL such as methotrexate (Mtx) and doxorubicin produce reactive oxygen species (ROS), a type of free radical. The ROS can reduce levels of antioxidants in the body, including superoxid...

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Bibliographic Details
Main Authors: Khalida Fetriyani Ningsih, Sri Mulatsih, Sasmito Nugroho
Format: Article
Language:English
Published: Indonesian Pediatric Society Publishing House 2015-10-01
Series:Paediatrica Indonesiana
Subjects:
Online Access:https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/42