Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model.

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model.

Neisseria meningitidis (the meningococcus) remains a major cause of bacterial meningitis and fatal sepsis. This commensal bacterium of the human nasopharynx can cause invasive diseases when it leaves its niche and reaches the bloodstream. Blood-borne meningococci have the ability to adhere to human...

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Bibliographic Details
Main Authors: Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009299

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https://doi.org/10.1371/journal.ppat.1009299

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