From DNA to RNA to disease and back: The 'central dogma' of regulatory disease variation

<p>Abstract</p> <p>Much of the focus of human disease genetics is directed towards identifying nucleotide variants that contribute to disease phenotypes. This is a complex problem, often involving contributions from multiple loci and their interactions, as well as effects due to en...

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Bibliographic Details
Main Authors: Stranger Barbara E, Dermitzakis Emmanouil T
Format: Article
Language:English
Published: BMC 2006-06-01
Series:Human Genomics
Subjects:
Online Access:http://www.humgenomics.com/content/2/6/383