Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development
The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain ‘orphan’ proteases and among them is ADAMTS18, which has been implicated in developmental eye diso...
Main Authors: | Dalya Ataca, Marian Caikovski, Alessandra Piersigilli, Alexandre Moulin, Charaf Benarafa, Sarah E. Earp, Yakir Guri, Corinne Kostic, Yvan Arsenivic, Raija Soininen, Suneel S. Apte, Cathrin Brisken |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2016-11-01
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Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/5/11/1585 |
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