1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling

1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling

Objectives: To explore the molecular mechanisms in which vitamin D (VD) regulates T cells, especially Th17 cells in collagen-induced arthritis (CIA).Methods: DBA1/J mice induced for CIA were intraperitoneally treated with VD. CIA clinical symptoms and inflammatory responses including Th1/Th17/Tregs...

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Bibliographic Details
Main Authors: Li Zhou, Julie Wang, Jingren Li, Ting Li, Yanming Chen, Rayford R. June, Song Guo Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
vitamin D
Th17 cells
IL-6R
miRNA-124
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00178/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00178/full

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