Defective Vagal Innervation in Murine Tbx1 Mutant Hearts

Defective Vagal Innervation in Murine Tbx1 Mutant Hearts

Haploinsufficiency of the T-box transcription factor TBX1 is responsible for many features of 22q11.2 deletion syndrome. Tbx1 is expressed dynamically in the pharyngeal apparatus during mouse development and Tbx1 homozygous mutants display numerous severe defects including abnormal cranial ganglion...

Full description

Bibliographic Details
Main Authors: Amélie Calmont, Naomi Anderson, Jenifer P. Suntharalingham, Richard Ang, Andrew Tinker, Peter J. Scambler
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
Tbx1
DiGeorge Syndrome
neural crest cells
cranial nerves
innervation
Online Access:http://www.mdpi.com/2308-3425/5/4/49

Internet

http://www.mdpi.com/2308-3425/5/4/49

Similar Items