Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections

Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections

Polymyxin B is used as a last therapeutic option for the treatment of multidrug-resistant Gram-negative bacterial infections. This study aimed to develop a population pharmacokinetic model and limited sampling strategy, a method to estimate the area under the concentration curve (AUC) by using a lim...

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Bibliographic Details
Main Authors: Peile Wang, Qiwen Zhang, Zhenfeng Zhu, Min Feng, Tongwen Sun, Jing Yang, Xiaojian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin B
population pharmacokinetics
limited sampling strategy
therapeutic drug monitoring
multidrug-resistant Gram-negative bacterial infection
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00829/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00829/full

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