Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-pre...

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Bibliographic Details
Main Authors: Shan He, Yongnian Liu, Lijun Meng, Hongxing Sun, Ying Wang, Yun Ji, Janaki Purushe, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, Jonathan Soboloff, Ran Reshef, Bethany Moore, Luca Gattinoni, Yi Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02187-8

Internet

https://doi.org/10.1038/s41467-017-02187-8

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