Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast

The budding yeast Saccharomyces cerevisiae represents an established model system to study the molecular mechanisms associated to neurodegenerative disorders. A key-feature of Parkinson’s disease is the formation of Lewy bodies, which are cytoplasmic protein inclusions. Misfolded α-synuclein is one...

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Bibliographic Details
Main Authors: Blagovesta Popova, Alexandra Kleinknecht, Gerhard H. Braus
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Biomolecules
Subjects:
α-synuclein
Parkinson’s disease
yeast
posttranslational modifications
aggregate clearance
autophagy
proteasome
Online Access:http://www.mdpi.com/2218-273X/5/2/617

Internet

http://www.mdpi.com/2218-273X/5/2/617

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