FusionAI: Predicting fusion breakpoint from DNA sequence with deep learning

Summary: Identifying the molecular mechanisms related to genomic breakage is an important goal of cancer mechanism studies. Among diverse locations of structural variants, fusion genes, which have the breakpoints in the gene bodies and are typically identified from the split reads of RNA-seq data, c...

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Bibliographic Details
Main Authors: Pora Kim, Hua Tan, Jiajia Liu, Mengyuan Yang, Xiaobo Zhou
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011329