Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Abstract Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onset of clinical symptoms. We have developed a...

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Bibliographic Details
Main Authors: Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Glutamate transporter EAAT2
Tauopathy
Small-molecule
rTg4510
Online Access:http://link.springer.com/article/10.1186/s13195-019-0530-z

Internet

http://link.springer.com/article/10.1186/s13195-019-0530-z

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