PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity

PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity

Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vaso...

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Bibliographic Details
Main Authors: Xingjuan Chen, Christian Egly, Ashley M. Riley, Wennan Li, Paul Tewson, Thomas E. Hughes, Anne Marie Quinn, Alexander G. Obukhov
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Cells
Subjects:
TRPC6
desensitization
DAG
PKC
H1 receptor
Online Access:http://www.mdpi.com/2073-4409/3/2/247

Internet

http://www.mdpi.com/2073-4409/3/2/247

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