Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution.

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution.

High throughput genome wide associations studies (GWAS) are now identifying a large number of genome loci related to risk of common human disease. Each such locus presents a challenge in identifying the relevant underlying mechanism. Here we report the experimental characterization of a proposed cau...

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Bibliographic Details
Main Authors: Natalia Gorlatova, Kinlin Chao, Lipika R Pal, Rawan Hanna Araj, Andrey Galkin, Illarion Turko, John Moult, Osnat Herzberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3210151?pdf=render

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http://europepmc.org/articles/PMC3210151?pdf=render

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