A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Abstract Immunotherapy has ushered in a new era of cancer therapy, and this is also applicable to therapy of hepatocellular carcinoma (HCC). In this context, effective development of therapeutic strategies requires an HCC mouse model with known tumor-associated antigens (TAAs) and an HCC growth repo...

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Bibliographic Details
Main Authors: Yu-Tzu Liu, Tai-Chung Tseng, Ruey-Shyang Soong, Chun-Yi Peng, Yu-Hsing Cheng, Shiu-Feng Huang, Tsung-Hsien Chuang, Jia-Horng Kao, Li-Rung Huang
Format: Article
Language:English
Published: BMJ Publishing Group 2018-12-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Hepatocellular carcinoma
T-cell exhaustion
Tumor-associated macrophage
MDSC
Tumor-specific T cell
Immune checkpoint
Online Access:http://link.springer.com/article/10.1186/s40425-018-0462-3

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http://link.springer.com/article/10.1186/s40425-018-0462-3

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