Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model

Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model

Newborns exposed to prenatal opioids often experience intense postnatal withdrawal after cessation of the opioid, called neonatal opioid withdrawal syndrome (NOWS), with limited pre- and postnatal therapeutic options available. In a prior study in pregnant mice we demonstrated that the peripherally...

Full description

Bibliographic Details
Main Authors: Alireza Safa, Allison R. Lau, Sydney Aten, Karl Schilling, Karen L. Bales, Victoria A. Miller, Julie Fitzgerald, Min Chen, Kasey Hill, Kyle Dzwigalski, Karl Obrietan, Mitch A. Phelps, Wolfgang Sadee, John Oberdick
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
opioid
neonatal
withdrawal
guinea pig
preventive
therapeutic
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.613328/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.613328/full

Similar Items