Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside’s putative relevance in wound healing, dermal fibrosis, and myofascial pain, we investigated the role of its precursor, AMP, and...

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Bibliographic Details
Main Authors: Carina Herman-de-Sousa, Ana Rita Pinheiro, Diogo Paramos-de-Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Teresa Magalhães-Cardoso, Severino Ribeiro, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
human subcutaneous fibroblasts
inosine
adenosine a<sub>2a</sub> receptor
adenosine a<sub>3</sub> receptor
exchange protein activated by cyclic amp (epac) pathway
cells proliferation
collagen production
Online Access:https://www.mdpi.com/2073-4409/9/3/651

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https://www.mdpi.com/2073-4409/9/3/651

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