MicroRNAs hsa-miR-618 and hsa-miR-297 Might Modulate the Pleiotropic Effects Exerted by Statins in Endothelial Cells Through the Inhibition of ROCK2 Kinase: in-silico Approach

MicroRNAs hsa-miR-618 and hsa-miR-297 Might Modulate the Pleiotropic Effects Exerted by Statins in Endothelial Cells Through the Inhibition of ROCK2 Kinase: in-silico Approach

Several studies show that statin therapy improves endothelial function by cholesterol-independent mechanisms called “pleiotropic effects.” These are due to the inhibition of the RhoA/ROCK kinase pathway, its inhibition being an attractive atheroprotective treatment. In addition, recent work has show...

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Bibliographic Details
Main Authors: Karla Leal, Kathleen Saavedra, Camilo Rebolledo, Luis A. Salazar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
statins
pleiotropic effects
microRNAs
atheroprotective effects
kinases
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.704175/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.704175/full

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