TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

Abstract Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively. Exact role of these polymorphisms in South Asian population wit...

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Bibliographic Details
Main Authors: Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Gastroenterology
Subjects:
Inflammatory bowel disease
Crohn’s disease
Ulcerative colitis
Cytopenia
Bone marrow suppression
6-mercaptopurine
Online Access:https://doi.org/10.1186/s12876-021-01900-8

Internet

https://doi.org/10.1186/s12876-021-01900-8

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