Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease

The loss of cognitive function in Alzheimer’s disease is pathologically linked with neurofibrillary tangles, amyloid deposition, and loss of neuronal communication. Cerebral insulin resistance and mitochondrial dysfunction have emerged as important contributors to pathogenesis supporting our hypothe...

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Bibliographic Details
Main Authors: Richard J. Johnson, Fernando Gomez-Pinilla, Maria Nagel, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Laura G. Sanchez-Lozada, Dean R. Tolan, Miguel A. Lanaspa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
fructose
sugar
uric acid
fructokinase
AMP deaminase
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.560865/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.560865/full

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