Caspase-8 mediates inflammation and disease in rodent malaria
Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.
Bibliographic Details
| Main Authors: |
Larissa M. N. Pereira,
Patrícia A. Assis,
Natalia M. de Araújo,
Danielle F. Durso,
Caroline Junqueira,
Marco Antônio Ataíde,
Dhelio B. Pereira,
Egil Lien,
Katherine A. Fitzgerald,
Dario S. Zamboni,
Douglas T. Golenbock,
Ricardo T. Gazzinelli |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18295-x
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