Caspase-8 mediates inflammation and disease in rodent malaria

Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.

Bibliographic Details
Main Authors:	Larissa M. N. Pereira, Patrícia A. Assis, Natalia M. de Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock, Ricardo T. Gazzinelli
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18295-x

id	doaj-86a724147e8a447f9b51209768df08e2
record_format	Article
spelling	doaj-86a724147e8a447f9b51209768df08e22021-09-19T11:51:25ZengNature Publishing GroupNature Communications2041-17232020-09-0111111310.1038/s41467-020-18295-xCaspase-8 mediates inflammation and disease in rodent malariaLarissa M. N. Pereira0Patrícia A. Assis1Natalia M. de Araújo2Danielle F. Durso3Caroline Junqueira4Marco Antônio Ataíde5Dhelio B. Pereira6Egil Lien7Katherine A. Fitzgerald8Dario S. Zamboni9Douglas T. Golenbock10Ricardo T. Gazzinelli11Instituto Rene Rachou, FIOCRUZ-MGDepartment of Medicine, University of Massachusetts Medical SchoolInstituto Rene Rachou, FIOCRUZ-MGDepartment of Medicine, University of Massachusetts Medical SchoolInstituto Rene Rachou, FIOCRUZ-MGInstituto Rene Rachou, FIOCRUZ-MGCentro de Pesquisas em Medicina Tropical, FIOCRUZ-RODepartment of Medicine, University of Massachusetts Medical SchoolDepartment of Medicine, University of Massachusetts Medical SchoolDepartamento de Biologia Celular Molecular e Bioagentes Patogenicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São PauloInstituto Rene Rachou, FIOCRUZ-MGInstituto Rene Rachou, FIOCRUZ-MGInflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.https://doi.org/10.1038/s41467-020-18295-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli
spellingShingle	Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli Caspase-8 mediates inflammation and disease in rodent malaria Nature Communications
author_facet	Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli
author_sort	Larissa M. N. Pereira
title	Caspase-8 mediates inflammation and disease in rodent malaria
title_short	Caspase-8 mediates inflammation and disease in rodent malaria
title_full	Caspase-8 mediates inflammation and disease in rodent malaria
title_fullStr	Caspase-8 mediates inflammation and disease in rodent malaria
title_full_unstemmed	Caspase-8 mediates inflammation and disease in rodent malaria
title_sort	caspase-8 mediates inflammation and disease in rodent malaria
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.
url	https://doi.org/10.1038/s41467-020-18295-x
work_keys_str_mv	AT larissamnpereira caspase8mediatesinflammationanddiseaseinrodentmalaria AT patriciaaassis caspase8mediatesinflammationanddiseaseinrodentmalaria AT nataliamdearaujo caspase8mediatesinflammationanddiseaseinrodentmalaria AT daniellefdurso caspase8mediatesinflammationanddiseaseinrodentmalaria AT carolinejunqueira caspase8mediatesinflammationanddiseaseinrodentmalaria AT marcoantonioataide caspase8mediatesinflammationanddiseaseinrodentmalaria AT dheliobpereira caspase8mediatesinflammationanddiseaseinrodentmalaria AT egillien caspase8mediatesinflammationanddiseaseinrodentmalaria AT katherineafitzgerald caspase8mediatesinflammationanddiseaseinrodentmalaria AT darioszamboni caspase8mediatesinflammationanddiseaseinrodentmalaria AT douglastgolenbock caspase8mediatesinflammationanddiseaseinrodentmalaria AT ricardotgazzinelli caspase8mediatesinflammationanddiseaseinrodentmalaria
_version_	1717375429131632640

Caspase-8 mediates inflammation and disease in rodent malaria

Similar Items