Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells

Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells

Abstract Background This study was aimed at investigating whether metformin can reverse the resistance of ovarian cancer cells to cisplatin and exploring the underlying mechanism. Methods Ovarian cancer cell proliferation in vitro was evaluated using a CCK-8 assay. The resistance index of platinum-r...

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Bibliographic Details
Main Authors: Juan Du, Hui-rong Shi, Fang Ren, Jing-lu Wang, Qing-hua Wu, Xia Li, Rui-tao Zhang
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Cancer
Subjects:
Cisplatin
DNA repair
Drug resistance
Hematoxylin and eosin staining
Immunohistochemistry
Insulin-like growth factor signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12885-017-3840-1

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http://link.springer.com/article/10.1186/s12885-017-3840-1

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