Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology

Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology

Summary: Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We, therefore, use single-c...

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Bibliographic Details
Main Authors: Austin E. Gillen, Kent A. Riemondy, Vladimir Amani, Andrea M. Griesinger, Ahmed Gilani, Sujatha Venkataraman, Krishna Madhavan, Eric Prince, Bridget Sanford, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Ken L. Jones, Siddhartha Mitra, Jay R. Hesselberth, Nicholas K. Foreman, Andrew M. Donson
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
ependymomasc
RNA-seq
classification
etiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310081

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http://www.sciencedirect.com/science/article/pii/S2211124720310081

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