Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer

Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer

We aimed to refine the value of CDX2 as an independent prognostic and predictive biomarker in colorectal cancer (CRC) according to disease stage and chemotherapy sensitivity in preclinical models. CDX2 expression was evaluated in 1045 stage I–IV primary CRCs by gene expression (n = 403) or immunohis...

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Bibliographic Details
Main Authors: Jarle Bruun, Anita Sveen, Rita Barros, Peter W. Eide, Ina Eilertsen, Matthias Kolberg, Teijo Pellinen, Leonor David, Aud Svindland, Olli Kallioniemi, Marianne G. Guren, Arild Nesbakken, Raquel Almeida, Ragnhild A. Lothe
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Molecular Oncology
Subjects:
CDX2
colorectal cancer
drug sensitivity
pharmacogenomics
predictive biomarker
prognostic biomarker
Online Access:https://doi.org/10.1002/1878-0261.12347

Internet

https://doi.org/10.1002/1878-0261.12347

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