Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function

Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function

Abstract We have reported that recombinant biglycan (BGN) core protein accelerates bone formation in vivo by enhancing bone morphogenetic protein (BMP)-2 function. The purpose of the present study was to identify the specific domain (“effector”) within the BGN core protein that facilitates BMP-2 ost...

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Bibliographic Details
Main Authors: Prapaporn Jongwattanapisan, Masahiko Terajima, Patricia A. Miguez, William Querido, Hideaki Nagaoka, Noriko Sumida, Elizabeth Grace Gurysh, Kristy M. Ainslie, Nancy Pleshko, Lalith Perera, Mitsuo Yamauchi
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25279-x

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https://doi.org/10.1038/s41598-018-25279-x

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