In Vitro Evaluation and Docking Studies of 5-oxo-5<i>H</i>-furo[3,2-<i>g</i>]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer’s Agents

In Vitro Evaluation and Docking Studies of 5-oxo-5<i>H</i>-furo[3,2-<i>g</i>]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer’s Agents

A series of novel 2-carbo&#8722;substituted 5-oxo-5<i>H</i>-furo[3,2-<i>g</i>]chromene-6-carbaldehydes and their 6-(4-trifluoromethyl)phenylhydrazono derivatives have been prepared and evaluated for biological activity against the human acetylcholinesterase (AChE) and but...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Samantha Gildenhuys, Emmanuel N. Agbo
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
5<i>h</i>-furo[3,2-<i>g</i>]chromen-5-ones
cholinesterases
β-secretase
lipoxygenases
anti-oxidant
cytotoxicity
molecular docking
Online Access:https://www.mdpi.com/1422-0067/20/21/5451

Internet

https://www.mdpi.com/1422-0067/20/21/5451

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