Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

Abstract Background Malaria is one of the most prevalent tropical infectious diseases. Since recently cases of artemisinin resistance were reported, novel anti-malarial drugs are required which differ from artemisinins in structure and biological target. The plasmodial glycogen synthase kinase-3 (Pf...

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Bibliographic Details
Main Authors: Andreas Masch, Abed Nasereddin, Arne Alder, Megan J. Bird, Sandra I. Schweda, Lutz Preu, Christian Doerig, Ron Dzikowski, Tim W. Gilberger, Conrad Kunick
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Malaria Journal
Subjects:
Anti-malarial drugs
Atropisomers
Axial chirality
Drug discovery
Malaria
PfGSK-3
Online Access:http://link.springer.com/article/10.1186/s12936-019-2725-y

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http://link.springer.com/article/10.1186/s12936-019-2725-y

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